DHT Hair Loss

Di-Hydrotestosterone (DHT) Caused Hair Loss

Testosterone is a sex corticosteroid that when converted to Di-Hydrotestosterone (DHT) is noted to be a leading cause of hair loss in men. Men and women have testosterone naturally produced by the adrenal glands and testis. Some testosterone is important for some biological process, especially for males including the deepening of the voice, development of muscles, and facial/body hair. Although men are most associated with testosterone, women have testosterone, although 1/3 the amount. The conversion of testosterone to DHT is shown to be a direct cause in some men’s hair loss. For reasons not exactly known, some men’s hair is more sensitive to DHT than others. Men tend to have an increase of testosterone brought on by puberty, and levels continue be about 3 times higher than their female counter parts until about middle age.

Testosterone is converted to Dihydrotesterone (DHT) via a complex biochemical process with many different chemical intermediates and enzymes. The enzyme 5-alpha-reductase (5-AR) is an important enzyme that essentially acts as the catalyst for production of DHT. Testosterone is present in blood circulates throughout the body, with the testosterone to 5 alpha reductase – DHT process occurring in the blood supply of the individual hair follicles. Over time (months or years) DHT can negatively affect the health and growth of a hair follicle. DHT can weaken the hair follicle and over time of reduced growth the hair can become smaller and smaller eventually so thin and atrophied that a new hair cannot grow.

DHT is also suggested to be involved with benign prostate hyperplasia and through the same mechanism of action (5-alpha-reductase), and coincidently the drug finasteride was discovered to help stop hair loss.

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